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Direct GLP-1 receptor effects on genital tract tissues: limited support for a direct vaginal target Mechanistic caution is warranted because direct GLP-1 receptor expression in vaginal tissue appears low by large transcriptomic resources

Here's what actually helps: Drink it cold chilled shakes are dramatically better tolerated than room-temperature ones

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The gap between trial and real-world tirzepatide vs semaglutide outcomes comes mostly from discontinuation and under-titration: only 25.9% of tirzepatide users reach 15 mg in practice, versus 83.5% of semaglutide users reaching 2.4 mg in the trial

At baseline, just over half of the men had total testosterone levels above 300 nanograms per deciliter (ng/dL)